52 results found
    1. Microbiology and Infectious Disease

    Strong inter-population cooperation leads to partner intermixing in microbial communities

    Babak Momeni, Kristen A Brileya ... Wenying Shou
    Simulations and experiments on systems containing two different populations of microorganisms show that interactions that benefit at least one of the populations can lead to communities with stable compositions, and that strong cooperation between two populations can lead to communities in which both populations are mixed together.
    1. Microbiology and Infectious Disease
    2. Ecology
    E. coli illustration

    The Natural History of Model Organisms: The unexhausted potential of E. coli

    Zachary D Blount
    A better understanding of the remarkable diversity, natural history and complex ecology of E. coli in the wild could shed new light on its biology and role in disease, and further expand its many uses as a model organism.
    1. Immunology and Inflammation

    Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema

    Ran You, Wen Lu ... Farrah Kheradmand
    The accumulation of carbon black nanoparticles in smokers' lungs causes sterile inflammation, double-strand DNA breaks and emphysema.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A general strategy to construct small molecule biosensors in eukaryotes

    Justin Feng, Benjamin W Jester ... David Baker
    A new method for developing biosensors from ligand binding domains that have concentration-dependent and selective responses to small molecules in yeast, mammalian cells and plants.
    1. Cancer Biology

    The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution

    Gui-Zhen Wang, Xin Cheng ... Guang-Biao Zhou
    The chemokine CXCL13 is critical to the development of air pollution- and tobacco smoke-induced lung cancers.
    1. Chromosomes and Gene Expression

    Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

    Joshua M Galanter, Christopher R Gignoux ... Noah Zaitlen
    An epigenome-wide study shows that ethnic self-identification and genetically determined ancestry both make important independent contributions to DNA methylation levels.
  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
    1. Developmental Biology
    2. Ecology

    Fish larval recruitment to reefs is a thyroid hormone-mediated metamorphosis sensitive to the pesticide chlorpyrifos

    Guillaume Holzer, Marc Besson ... Vincent Laudet
    Coral reef fish larval recruitment is a metamorphosis that can be disturbed by reef pollutants, as it is under the influence of the environment through the direct control of thyroid hormone signaling.
    1. Ecology

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle, Christian R Boehm ... William J Sutherland
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck, Elena Cassella ... Paul D Bieniasz
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.

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