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    1. Immunology and Inflammation

    FoxO factors are essential for maintaining organ homeostasis by acting as stress sensors in airway epithelial cells

    Karin Uliczka, Judith Bossen ... Thomas Roeder
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Cell Biology

    Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

    Samarpan Maiti, Kaushik Bhattacharya ... Didier Picard
    Human cells adapt to chronic mild stresses, such as slightly elevated temperature, by getting larger in a process that couples increased translation to increased cell size in an Hsp90-dependent manner.
    1. Ecology
    2. Evolutionary Biology

    Sensory collectives in natural systems

    Hannah J Williams, Vivek H Sridhar ... Amanda D Melin
    A synthetic, prospective article considers how the fields of sensory ecology and collective behaviour can combine when considering animal collective movements and interactions, and how these fields can inspire each other to advance understanding of animal behaviour, adaptation and evolution.
    1. Computational and Systems Biology
    2. Ecology

    100 years of anthropogenic impact causes changes in freshwater functional biodiversity

    Niamh Eastwood, Jiarui Zhou ... Luisa Orsini
    High-throughput systemic approaches on long-term trends identify the environmental factors that cause loss of biodiversity and disrupt ecosystem functions.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.
    1. Cell Biology

    Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis

    Emmeline Marchal-Duval, Méline Homps-Legrand ... Arnaud A Mailleux
    Inhibition of a single fibroblast-associated transcription factor, namely Paired-related Homeobox Protein 1 (PRRX1), is sufficient to dampen lung fibrogenesis.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Epidemiology and Global Health

    Disentangling the rhythms of human activity in the built environment for airborne transmission risk: An analysis of large-scale mobility data

    Zachary Susswein, Eva C Rest, Shweta Bansal
    Fine-grain mobility data empirically quantify the propensity for human mixing to be indoors across the US and improve understanding of the relationship between the physical environment and infection risk in light of global change.
    1. Cancer Biology

    The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

    Katarína Balážová, Hans Clevers, Antonella FM Dost
    As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.