4,304 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley et al.
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Computational and Systems Biology

    Dynamic control of gene regulatory logic by seemingly redundant transcription factors

    Zohreh AkhavanAghdam et al.
    Seemingly redundant homologous transcription factors play distinct and cooperative roles in time-dependent combinatorial gene regulation and enable dynamic control of heterogeneity in the gene responses to environmental stresses.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    A simple regulatory architecture allows learning the statistical structure of a changing environment

    Stefan Landmann et al.
    Minimal modifications of common regulatory circuits can allow bacteria to learn from the past to better predict the future, on a physiological, rather than evolutionary, timescale.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic tuning of gene expression enables cellular adaptation in the absence of pre-existing regulatory circuitry

    Peter L Freddolino et al.
    Stochastic tuning of gene expression could be a common mechanism through which eukaryotic cells adapt to challenging external environments, potentially including survival of infectious organisms within the host and adaptation of cancer cells to chemotherapy.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Genetics and Genomics

    On the mechanistic nature of epistasis in a canonical cis-regulatory element

    Mato Lagator et al.
    Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
    1. Computational and Systems Biology
    2. Neuroscience

    Regulation of sleep homeostasis by sexual arousal

    Esteban J Beckwith et al.
    Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.
    1. Developmental Biology

    Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

    Shawn A Hallett et al.
    Slow-cycling chondrocytes are maintained in a Wnt-inhibitory environment within the resting zone, unraveling a novel mechanism regulating maintenance and differentiation of parathyroid hormone-related protein (PTHrP)-expressing skeletal stem cells of the postnatal growth plate.
    1. Neuroscience

    A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

    June K Corrigan et al.
    The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Natural antisense transcripts regulate the neuronal stress response and excitability

    Xingguo Zheng et al.
    The mRNA that encodes a Drosophila sodium channel enables neurons to adapt to acute temperature changes, via a mechanism independent of its protein-coding role.

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