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    1. Ecology

    Stability and asynchrony of local communities but less so diversity increase regional stability of Inner Mongolian grassland

    Yonghui Wang, Shaopeng Wang ... Bernhard Schmid
    The regional stability across distant local communities is related to the stability of and asynchronous dynamics among local communities, which are strongly impacted by population dynamics of a few abundant species and relative weakly by species diversity.
    1. Cell Biology
    2. Computational and Systems Biology

    Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

    Andrew D Bailey, Jason Talkish ... Manuel Ares
    A method enabling identification of more than 100 RNA modifications in single ribosomal RNA molecules uncovers new classes of modified ribosomes.
    1. Chromosomes and Gene Expression

    Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

    R A Greenstein, Stephen K Jones ... Bassem Al-Sady
    Heterochromatin spreading in fission yeast predominantly produces intergenerationally unstable outcomes, requiring an accessory element that represses histone turnover.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Demographic reconstruction from ancient DNA supports rapid extinction of the great auk

    Jessica E Thomas, Gary R Carvalho ... Michael Knapp
    Reconstruction of great auk population dynamics suggests that hunting pressure alone could have been responsible for their extinction, demonstrating that even abundant, widespread species can be vulnerable to intense exploitation.
    1. Plant Biology

    Increased signal-to-noise ratios within experimental field trials by regressing spatially distributed soil properties as principal components

    Jeffrey C Berry, Mingsheng Qi ... Rebecca S Bart
    A method to reduce the noise present in field experiments by accounting for heterogeneity in field soils.
    1. Structural Biology and Molecular Biophysics

    Modulation of α-synuclein aggregation amid diverse environmental perturbation

    Abdul Wasim, Sneha Menon, Jagannath Mondal
    A comprehensive exploration of α-synuclein (αS) aggregation dynamics from both macroscopic and microscopic perspectives uncovers the intricate mechanisms underlying crowder and salt-induced intensification of αS self-aggregation.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    NF-κB oscillations translate into functionally related patterns of gene expression

    Samuel Zambrano, Ilario De Toma ... Alessandra Agresti
    NF-κB oscillations synchronize to external perturbations as a damped oscillator, producing different transcription dynamics.
    1. Ecology
    2. Epidemiology and Global Health

    Landscape drives zoonotic malaria prevalence in non-human primates

    Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace
    Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
    1. Ecology
    2. Genetics and Genomics

    Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities

    Henrik Krehenwinkel, Sven Weber ... Michael Veith
    Environmental DNA from highly standardized leaf sample time series suggests no localized species losses, but biotic turnover and homogenization, as main drivers of forest insect decline.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

    Karl P Hodel, Richard de Borja ... Zachary F Pursell
    When mismatch repair is compromised heterozygous loss of Pol ε proofreading is sufficient to drive a subset of the observed clinical characteristics of Pol ε tumors.