636 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic et al.
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Computational design of environmental sensors for the potent opioid fentanyl

    Matthew J Bick et al.
    State-of-the-art computational methods have facilitated the construction of plant-based sentinels for detecting toxic molecules in the environment.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code

    Tammy J Bullwinkle et al.
    Translation quality control protects the cell from environmental stresses that could potentially lead to the toxic accumulation of non-proteinogenic amino acids in the proteome.
    1. Chromosomes and Gene Expression

    Paternal Effects: Like father, like son

    Claude Becker
    Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.
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    1. Developmental Biology

    The Natural History of Model Organisms: An organismal perspective on C. intestinalis development, origins and diversification

    Matthew J Kourakis, William C Smith
    The life cycle and morphology of the sea squirt Ciona intestinalis shed light on vertebrate evolution.
    1. Ecology
    2. Plant Biology

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolism: Division of labor in bacteria

    Alma Dal Co et al.
    The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria.
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    1. Microbiology and Infectious Disease

    Phage Predation: Killing the killers

    Marianne De Paepe, Marie-Agnès Petit
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    1. Developmental Biology
    2. Immunology and Inflammation

    Symbiosis: Protection from within

    Florent Masson, Bruno Lemaitre
    The development of the tsetse fly immune system relies on a cue from an endosymbiotic bacterium called Wigglesworthia.
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