1,466 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Bacterial cell cycle control by citrate synthase independent of enzymatic activity

    Matthieu Bergé et al.
    A key enzyme of central energy metabolism, citrate synthase, regulates bacterial cell cycle progression at a very specific stage (S-phase) and independently of its enzymatic activity.
    1. Plant Biology

    A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection

    Shanshan Zhao et al.
    Rice dwarf virus Pns11 protein increases rice susceptibility to virus infection by enhancing OsSAMS1 enzymatic activity and ethylene production.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas et al.
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations

    Pei-Ling Tsai et al.
    Lamin B receptor may provide a long-sought model system enabling unprecedented studies of protein quality control in the nuclear envelope of mammalian cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry et al.
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

    Cara C Boutte et al.
    Cell wall biosynthesis in mycobacteria is regulated by an unusual post-translational regulatory system that contributes to antibiotic tolerance during stress.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism

    Robert J Nichols et al.
    A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
    1. Biochemistry and Chemical Biology

    Diverse nucleosome Site-Selectivity among histone deacetylase complexes

    Zhipeng A Wang et al.
    By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

    Iordan Iordanov et al.
    TRPM2 is simply a ligand gated channel and does not to possess enzymatic activity, even though it shows sequence similarity to Nudix hydrolases.
    1. Biochemistry and Chemical Biology

    Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH

    Joon T Kim et al.
    Enzymatic division of labor is identified as an enabling biochemical strategy for regulating a family of structurally diverse bioactive lipids.

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