3,496 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez et al.
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach et al.
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.
    1. Biochemistry and Chemical Biology

    Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

    Brent W Anderson et al.
    The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.
    1. Biochemistry and Chemical Biology

    Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site

    Fanny Sunden et al.
    Conventional studies have focused on enzymatic residues directly involved in catalysis; dissecting a potential interaction network within which these ‘catalytic residues’ are embedded provides insights fundamental to enzyme function, evolution, and engineering.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

    Kelsi R Hall et al.
    Evolving E. coli NfsA for enhanced chloramphenicol detoxification in the native host environment shows that eliminating substrate competition can occur rapidly, and be key to evolving a new enzymatic function.
    1. Cell Biology

    The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack

    Hieng Chiong Tie et al.
    Transport machinery localizes at the cisternal rim while modification machinery localizes at the interior.
    1. Evolutionary Biology
    2. Plant Biology

    Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway

    Gaurav D Moghe et al.
    Integrative analysis of a specialized metabolic pathway across multiple non-model species illustrates mechanisms of emergence of chemical novelty in plant metabolism.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases

    Rahil Taujale et al.
    Deep mining of GT-A fold sequences provides an evolutionary framework for investigating complex relationships connecting GT-A fold sequence, structure, function and regulation.
    1. Structural Biology and Molecular Biophysics
    2. Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Computational and Systems Biology
    2. Plant Biology

    Evolution of C4 photosynthesis predicted by constraint-based modelling

    Mary-Ann Blätke, Andrea Bräutigam
    Constraint-based modelling predicts C4 photosynthesis evolves under resource limitation from an ancestral ground state of C3 photosynthesis and attributes divergent metabolic routes in extant C4 subtypes to light.

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