3,372 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry et al.
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Biochemistry and Chemical Biology

    Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction

    Brent W Anderson et al.
    The signaling ligand (p)ppGpp regulates the enzyme HPRT across species by binding to a novel class of conserved motif, yet its specificity is allosterically altered through evolution of enzyme oligomerization.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations

    Nicole Hajicek et al.
    The high-resolution X-ray crystal structure of PLC-γ1 reveals a unifying model for the regulation of the PLC-γ isozymes.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail

    Johanna Ludwigsen et al.
    The N-terminal domain of the chromatin remodeler ISWI contains previously uncharacterized conserved motifs that maintain structure, prevent ATP hydrolysis unless nucleosomes are bound, and confer H4-tail sensitivity without directly competing with the H4 tail.
    1. Biochemistry and Chemical Biology

    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

    Nam Chu et al.
    NMR and biochemical analysis reveal new insights into how the critical protein kinase Akt is regulated by phosphorylation and is inhibited by an experimental therapeutic.
    1. Plant Biology

    Regulation of photosynthetic electron flow on dark to light transition by ferredoxin:NADP(H) oxidoreductase interactions

    Manuela Kramer et al.
    The regulatory switch from protection to assimilation, which plants use to exploit natural, fluctuating light, involves movement of the enzyme ferredoxin:NADP(H) oxidoreductase between chloroplast membrane complexes.
    1. Cell Biology

    The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

    Sam A Menzies et al.
    CRISPR/Cas9 genome-wide screens using sterol-sensitive endogenous HMG-CoA reductase (HMGCR) reporter identify the sterol-responsive RNF145 and gp78 as independently responsible for sterol-accelerated degradation of HMGCR, the rate-limiting enzyme of cholesterol biosynthesis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

    Johanne Le Coq et al.
    The SHIP2 inositol phosphatase is an important upstream regulator of the Akt signaling pathway, which requires a catalytic core formed by the phosphatase domain tightly packed to a C2 domain for its function.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation

    Li Li et al.
    Proteasome-mediated degradation of the TATA-box binding protein (TBP) during terminal differentiation is regulated by the E3 ligase Huwe1 and the deubiquitinase USP10.

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