2,785 results found
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

    Alan Sulpizio et al.
    The pseudokinase-like Legionella effector SidJ catalyzes the glutamylation of bacterial ubiquitin ligases in a calmodulin-dependent manner.
    1. Cell Biology
    2. Genetics and Genomics

    Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

    David W Morgens et al.
    Using a suite of CRISPR technologies, unique chemical tools, and carefully designed biochemical and cell biological assays, we define the mechanism of action of Retro-2, an inhibitor of retrograde toxins.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Genetics and Genomics

    An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

    Oguz Kanca et al.
    Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..
    1. Cell Biology
    2. Developmental Biology

    Single-cell proteomics reveals changes in expression during hair-cell development

    Ying Zhu et al.
    Protein mass spectrometry can be used to uncover developmental trajectories in small single cells of differentiating tissues.
    1. Structural Biology and Molecular Biophysics

    Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

    Janelle Lauer et al.
    Understanding the complex auto-regulatory mechanisms for guanine nucleotide exchange factors is critically important for fully appreciating the layers of control for small GTPases.
    1. Neuroscience

    Behavior: The cerebellum shows its stripes

    Ashley L Holloway, Talia N Lerner
    New studies examine how the different sub-structures in the cerebellum are organized to receive information during complex behavioral tasks.
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    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Human Biology and Medicine

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Biochemistry and Chemical Biology

    PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

    Kerryn Berndsen et al.
    PPM1H protein phosphatase dephosphorylates Rab proteins modulating LRRK2 signalling.

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