3,282 results found
    1. Neuroscience

    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

    Genjiro Suzuki et al.
    One α-synuclein strain inhibited proteasome activity and induced apparent pathologies, while the other did not, indicating a strain-dependent toxicity of α-synuclein aggregates, which support a prion-like behavior of α-synuclein.
    1. Cancer Biology

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Allison N Lau et al.
    Isotope tracing into macromolecules enables functional analysis of metabolism in specific cell populations in tumors and provides insight into metabolic differences between cancer and stromal cells in their endogenous microenvironment.
    1. Physics of Living Systems

    A minimal self-organisation model of the Golgi apparatus

    Quentin Vagne et al.
    An unbiased model for the self-organisation of the Golgi apparatus displays either anterograde vesicular transport or cisternal maturation depending on ratios of budding, fusion and biochemical conversion rates.
    1. Genetics and Genomics

    Telomeres: Getting to grips with circular chromosomes

    Constance Nugent, Katsunori Sugimoto
    A strain of budding yeast that contains one large chromosome reveals how the telomere capping complex CST maintains linear but not circular chromosomes.
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    1. Genetics and Genomics

    Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions

    Zhi-Jing Wu et al.
    Cdc13 prevents chromosomes from end-to-end fusion.
    1. Neuroscience

    Keratinocytes contribute to normal cold and heat sensation

    Katelyn E Sadler et al.
    Purinergic keratinocyte-to-sensory neuron signaling is a ubiquitous amplification mechanism that is required for normal mechanical, cold, and heat sensation in vivo.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Transposase-assisted tagmentation of RNA/DNA hybrid duplexes

    Bo Lu et al.
    Tn5 transposase has direct tagmentation activity towards RNA/DNA hybrids, which is harnessed as a more convenient and faster RNA-seq library construction method and will benefit RNA and chromatin research.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

    George Ueda et al.
    De novo protein nanoparticles were designed from scratch to present viral glycoprotein antigens, providing a systematic way to study the influence of antigen presentation geometry on immune response.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor

    Nami Kitajima et al.
    Hybrid-type fluorescent ATP sensor showing submicromolar affinity, a large fluorescence response, high selectivity and pH-independence visualized extracellular ATP dynamics in the brain of living mice with high spatiotemporal resolution.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    S-phase-independent silencing establishment in Saccharomyces cerevisiae

    Davis Goodnight, Jasper Rine
    Cell-cycle progression is crucial for heterochromatin formation in budding yeast because S phase promotes the removal of active chromatin marks.

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