2,694 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen et al.
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Developmental Biology
    2. Evolutionary Biology

    Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development

    Sruthi Purushothaman et al.
    While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu et al.
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Evolutionary Biology

    Molecular function limits divergent protein evolution on planetary timescales

    Mariam M Konaté et al.
    Orthologous proteins that continuously maintain the same molecular function do not usually diverge beyond a certain level of sequence and structural similarity.
    1. Cell Biology
    2. Plant Biology

    Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

    Charlotte Kirchhelle et al.
    In lateral roots, cells employ a novel pathway to cell edges to control directional growth, which acts independently of the leading paradigm of oriented deposition of cellulose microfibrils at faces.
    1. Cell Biology
    2. Human Biology and Medicine

    Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity

    Kasparas Petkevicius et al.
    Obesity leads to increased phosphatidylcholine turnover in adipose tissue macrophages that makes them susceptible to saturated fatty acid-induced inflammation.
    1. Neuroscience

    Evolution of neuronal anatomy and circuitry in two highly divergent nematode species

    Ray L Hong et al.
    The substrate for evolutionary divergence does not lie in changes in neuronal cell number or targeting, but rather in sensory perception and synaptic partner choice within invariant, prepatterned neuronal processes.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

    Isabella Vlisidou et al.
    The insect pathogenic bacterium Photorhabdus has evolved astonishing nano-scale analogues of hypodermic syringes that it uses to inject toxins into host cells.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen et al.
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Structural Biology and Molecular Biophysics

    Transcription: Overcoming chromatin barriers

    Babette E de Jong, John van Noort
    Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
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