Many scientific terms have been borrowed from ancient languages, but their modern usage often overlooks their etymology, as do many new terms coined by scientists.

Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.

Rigorous biophysical studies reconcile several conflicting views on how cGAS is activated, and present a new unifying allosteric activation mechanism.

Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.

Biochemical approaches reveal that an epigenetic histone deacetylase complex called CoREST is slow to deacetylate histone H3 lysine-14 in nucleosomes, and this inhibits demethylation of histone H3 lysine-4 by the CoREST complex.

The conformations of the enzyme cyclophilin A that are essential for its catalytic activity are temperature dependent and exhibit diverse responses, which is consistent with a complex energy landscape.

Philosophy may help to explore the potential impacts of synthetic cells.

Lysosomes are highly enriched in chloride, which is essential for their degradative function.

Proteomic, biochemical and cell-based analyses of the heterodecameric core GID/CTLH E3 ligase complex reveal its molecular architecture, activity determinants, and function in targeting the tumor suppressor Hbp1 and other substrates required for cell proliferation.

Data-driven methods predict over 35 mosquitoes are potential vectors of Zika virus, suggesting a larger geographic area and a greater human population is at risk of infection.