851 results found
    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai et al.
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Developmental Biology

    Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

    Lori L O'Brien et al.
    Wnt11 maintains nephron progenitor niche integrity during kidney development through its modulation of cellular dynamics.
    1. Cell Biology

    Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

    Mirko Messa et al.
    Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Nephron progenitor commitment is a stochastic process influenced by cell migration

    Kynan T Lawlor et al.
    Stochastic cell migration modulates exposure to signals that regulate commitment in the nephron progenitor niche.
    1. Cell Biology
    2. Developmental Biology

    EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

    Maike Frye et al.
    EphrinB2/EphB4-mediated regulation of cytoskeletal contractility is a key homeostatic mechanism of lymphatic endothelial cell-cell junction maintenance, and provides a potential target for therapeutic modulation of lymphatic vessel permeability and function.
    1. Developmental Biology

    Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

    Kieran M Short et al.
    Analysing developing mouse kidneys demonstrates nephron formation does not significantly impact branching morphogenesis of the ureteric bud, suggesting this process is distinct from branching in organs like the mammary gland.
    1. Developmental Biology

    Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers

    Nanoka Suzuki et al.
    Arid3a, a component of H3K9 me3 demethylases, regulates regeneration of the proximal nephric tubule through the evolutionarily conserved regeneration signal-response enhancer.
    1. Cancer Biology
    2. Cell Biology

    EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells

    Benjamin Krusche et al.
    EphrinB2 promotes glioblastoma stem-like cell malignancy through the interplay of cell-autonomous and non-cell-autonomous mechanisms and its targeting suppresses tumourigenesis in preclinical models of human glioblastoma.
    1. Developmental Biology
    2. Neuroscience

    Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

    Sebastian Poliak et al.
    The Netrin-1 and ephrin-B2 proteins act synergistically in the developing nervous system.
    1. Developmental Biology
    2. Neuroscience

    Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance

    Felix Fiederling et al.
    A distinctive novel mechanism of ephrin-A/EphA signaling modulation in retinal growth cones ensures concurrent quantitative accuracy and adaptability of topographic hardwiring.

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