66 results found
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.
    1. Stem Cells and Regenerative Medicine

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

    Jan J Zylicz et al.
    Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.
    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems Biology: A new way to build cell lineages

    Xiuwei Zhang, Nir Yosef
    A combination of single-cell techniques and computational analysis enables the simultaneous discovery of cell states, lineage relationships and the genes that control developmental decisions.
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    1. Developmental Biology

    Totipotency: A developmental insurance policy

    Nestor Saiz, Anna-Katerina Hadjantonakis
    Why does a totipotent state linger within the inner cell mass of mouse embryos?.
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    1. Developmental Biology

    Cell Fate Choice: Survival of the fattest

    Sophie M Morgani, Joshua M Brickman
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    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.

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