624 results found
    1. Cell Biology
    2. Developmental Biology

    Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

    Mariko Yokouchi et al.
    The three dimensional structure of epidermal cells in the stratum granulosum provides the basis for the homeostasis of the tight junction barrier during cell turnover in the skin.
    1. Cell Biology
    2. Immunology and Inflammation

    Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

    Sara Cipolat et al.
    A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.
    1. Immunology and Inflammation

    Epidermal RAF prevents allergic skin disease

    Josipa Raguz et al.
    In keratinocytes, the BRAF and RAF1 proteins work independently to balance the activity of mitogenic and stress kinase cascades and uphold the mechanical and immunological barrier functions of the epidermis.
    1. Cell Biology

    Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1

    Yajuan Guo et al.
    Keratin filaments are revealed as novel regulators of entry into terminal differentiation in the epidermis via an ability to modulate YAP1 function and Hippo signaling.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

    Thomas W Bebee et al.
    Large-scale developmental defects in mice occur with the ablation of the epithelial-specific splicing factors Esrp1 and Esrp2.
    1. Developmental Biology

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe et al.
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Cell Biology
    2. Developmental Biology

    Cytoskeletal tension and Bazooka tune interface geometry to ensure fusion fidelity and sheet integrity during dorsal closure

    Piyal Taru Das Gupta, Maithreyi Narasimha
    Restoration of molecular and morphological symmetry and mechanical integrity following epithelial fusion relies on adaptive changes that are mediated by cytoskeletal tension and Bazooka dependent modulation of fusing interface geometry.
    1. Immunology and Inflammation

    Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

    Theresa Benezeder et al.
    Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.
    1. Developmental Biology

    A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms

    Chiara Azzi et al.
    Distinct regulation endows two isoforms of the transcription factor LIN-29 with distinct functions to achieve coordinated execution of separate juvenile-to-adult transition events in Caenorhabditis elegans..
    1. Medicine

    Cardiovascular adaptation to hypoxia and the role of peripheral resistance

    Andrew S Cowburn et al.
    Radiotelemetric and genetic studies of peripheral tissue response show that a peripheral tissue can dynamically alter cardiovascular adaptation to changes in environmental oxygen.

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