Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
Elucidation of the molecular basis of early wound epidermis dependence during salamander limb regeneration reveals midkine as a key modulator of wound epidermis development and wound-healing resolution.
Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
The three dimensional structure of epidermal cells in the stratum granulosum provides the basis for the homeostasis of the tight junction barrier during cell turnover in the skin.
A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.
A method to assess the risk of self-sustained HIV transmission in heterosexuals from phylogenetic and epidemiological data is developed and, when applied to the Swiss HIV epidemic, shows that this risk is negligibly small for Switzerland.
The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.
Heterogeneous epidermal stem cells define a niche for tactile sensation via providing a unique ECM and tissue architecture for nerves, revealing their new functions in coordinated sensory organ formation.
