876 results found
    1. Developmental Biology

    Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception

    Shu Yang et al.
    The apparently incompatible functions of the Hedgehog co-receptor Ihog in homophilic adhesion and ligand binding cooperate in Hh transport and reception.
    1. Cancer Biology

    Limited inhibition of multiple nodes in a driver network blocks metastasis

    Ali Ekrem Yesilkanal et al.
    Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
    1. Cell Biology

    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

    Stéphanie Torrino et al.
    UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
    1. Cell Biology

    Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

    Jennifer M Kunselman et al.
    Different dynorphins, which signal similarly from the cell surface, can differentially localize G protein-coupled receptors to specific subcellular compartments and cause divergent receptor fates and distinct spatiotemporal patterns of signaling.
    1. Biochemistry and Chemical Biology

    Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

    Qiang Liu et al.
    Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi et al.
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Immunology and Inflammation

    Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

    Jianpeng Sheng et al.
    Fate mapping analysis shows that not bona fide Langerhans cells but their ‘look-alikes’ dermal Langerhans cell-like cells migrate to the lymph nodes.
    1. Immunology and Inflammation

    Skin Immunity: A new player in the dermis

    Gyohei Egawa, Kenji Kabashima
    Langerhans-like cells located in the dermis can travel to lymph nodes where they modulate immune responses.
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    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

    Carter J Barger et al.
    FOXM1 is co-expressed with its bidirectional gene partner RHNO1, and the two genes promote DNA repair, cell growth and survival, and chemotherapy resistance in ovarian cancer.

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