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870 results found
    1. Developmental Biology

    Type XVII collagen coordinates proliferation in the interfollicular epidermis

    Mika Watanabe et al.
    Type XVII collagen, a transmembranous protein in basal keratinocytes, suppresses interfollicular epidermal proliferation in neonatal and aged skin, and helps rejuvenate epidermis.
    1. Ecology
    2. Evolutionary Biology

    CRISPR-based herd immunity can limit phage epidemics in bacterial populations

    Pavel Payne et al.
    Bacteria can exhibit herd immunity protection against phages, which may play a significant role in their ecology and evolution.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

    Ajay Mishra et al.
    A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration

    Stephanie L Tsai et al.
    Elucidation of the molecular basis of early wound epidermis dependence during salamander limb regeneration reveals midkine as a key modulator of wound epidermis development and wound-healing resolution.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

    Emma Carley et al.
    Forces stemming from cell-matrix adhesions, but not cell-cell adhesions, are directly transmitted to the nuclear lamina to regulate epidermal cell fate.
    1. Cell Biology
    2. Developmental Biology

    Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

    Mariko Yokouchi et al.
    The three dimensional structure of epidermal cells in the stratum granulosum provides the basis for the homeostasis of the tight junction barrier during cell turnover in the skin.
    1. Cell Biology
    2. Developmental Biology

    FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis

    Melissa Kelley et al.
    A fibrillin-related protein, FBN-1, is a key component of the apical extracellular matrix and prevents epidermal cell deformation by biomechanical forces during morphogenesis of the C. elegans embryo.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis

    Teja Turk et al.
    A method to assess the risk of self-sustained HIV transmission in heterosexuals from phylogenetic and epidemiological data is developed and, when applied to the Swiss HIV epidemic, shows that this risk is negligibly small for Switzerland.
    1. Cell Biology
    2. Developmental Biology

    Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

    Kimberly C Tu et al.
    The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.
    1. Stem Cells and Regenerative Medicine
    2. Developmental Biology

    Hair follicle epidermal stem cells define a niche for tactile sensation

    Chun-Chun Cheng et al.
    Heterogeneous epidermal stem cells define a niche for tactile sensation via providing a unique ECM and tissue architecture for nerves, revealing their new functions in coordinated sensory organ formation.

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