125 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin

    Gergana Shipkovenska et al.
    Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.
    1. Chromosomes and Gene Expression

    Intergenerational epigenetic inheritance of cancer susceptibility in mammals

    Bluma J Lesch et al.
    Genetic knockout of the histone demethylase Kdm6a in the mouse germ line leads to elevated cancer incidence in genetically wild type offspring.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance

    Scott Berry et al.
    Two copies of a Polycomb target gene in the same cell can be maintained in independently heritable expression states, demonstrating that long-term memory of gene expression is stored locally.
    1. Chromosomes and Gene Expression

    Epigenetic memory independent of symmetric histone inheritance

    Daniel S Saxton, Jasper Rine
    Reduced fidelity of histone inheritance has minimal effects on inheritance of epigenetic states of heterochromatin in Saccharomyces..
    1. Neuroscience

    Epigenetic inheritance of circadian period in clonal cells

    Yan Li et al.
    Global changes in gene expression associated with differential DNA methylation underlie epigenetic inheritance of circadian periodicity in cells.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Developmental Biology

    Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

    Georges Raad et al.
    Predisposition to obesity-associated diseases is dependent on the ancestors' diet.
    1. Chromosomes and Gene Expression

    Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability

    R A Greenstein et al.
    Heterochromatin spreading in fission yeast predominantly produces intergenerationally unstable outcomes, requiring an accessory element that represses histone turnover.
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase

    Gulzhan Raiymbek et al.
    A putative histone demethylase in fission yeast has non-enzymatic properties that regulates heterochromatin assembly and epigenetic inheritance.

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