ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.
BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
At the transition from intrauterine to postnatal life, drastic environmental alterations are mirrored by changes in cellular immunity, which are in part immune cell intrinsic and have lasting health impact.
Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.