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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic insights into volatile anesthetic modulation of K2P channels

    Aboubacar Wague et al.
    The volatile anesthetic isoflurane directly binds to the transmembrane domains of the TREK1 channel to allosterically modulate its function.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen

    David E Cook et al.
    Assessment of DNA methylation, histone modifications, and DNA accessibility revealed that physical DNA characteristics are associated with adaptive genome evolution in the broad host range plant pathogenic fungus Verticillium dahliae.
    1. Computational and Systems Biology
    2. Neuroscience

    Reconsidering the evidence for learning in single cells

    Samuel J Gershman et al.
    Single cells are believed to be incapable of complex forms of learning, but reconsideration of historical studies and more recent developments suggest that this orthodoxy must now be reconsidered.
    1. Evolutionary Biology

    Phylogenomics of white-eyes, a ‘great speciator’, reveals Indonesian archipelago as the center of lineage diversity

    Chyi Yin Gwee et al.
    Contrary to the high absolute number of white-eyes in other parts of the world, the Indonesian archipelago is the center of phylogenetic diversity of this great speciator.
    1. Immunology and Inflammation

    The leukocyte non-coding RNA landscape in critically ill patients with sepsis

    Brendon P Scicluna et al.
    Long non-coding RNA profiles as a source of signal in sepsis.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas et al.
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy et al.
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Immunology and Inflammation

    Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs

    Sofya A Kasatskaya et al.
    Functional subsets of helper CD4+ T cells carry TCR repertoires with distinct features that are reproducible across donors and are partially acquired at the level of thymic selection.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel et al.
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Evolutionary Biology

    Adaptive evolution of an essential telomere protein restricts telomeric retrotransposons

    Bastien Saint-Leandre et al.
    Evolution strictly preserves telomere stability but rapidly diversifies telomere length regulation in Drosophila.