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    1. Chromosomes and Gene Expression

    HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

    Jonathan E Reeder et al.
    Tat uses unexpected regulatory mechanisms to reprogram target immune cells to promote viral replication and rewire pathways beneficial for HIV.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance

    Scott Berry et al.
    Two copies of a Polycomb target gene in the same cell can be maintained in independently heritable expression states, demonstrating that long-term memory of gene expression is stored locally.
    1. Computational and Systems Biology
    2. Developmental Biology

    A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

    Kenneth KH Ng et al.
    The timing and outcome of mammalian cell lineage decisions can be controlled by slow, stochastic events on individual regulatory gene loci.
    1. Cell Biology

    Dnmt3a is an epigenetic mediator of adipose insulin resistance

    Dongjoo You et al.
    Mouse and tissue culture studies reveal that adipose DNA methyltransferase 3a mediates insulin resistance, partially through repressing the expression of FGF21.
    1. Genetics and Genomics

    Pervasive epigenetic effects of Drosophila euchromatic transposable elements impact their evolution

    Yuh Chwen G Lee, Gary H Karpen
    The ability of transposable elements to epigenetically influence adjacent genes impacts genome evolution by driving substantial variation in transposon numbers between species.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs

    Robin E Harris et al.
    Localized silencing of damage-responsive enhancers can block regenerative growth while permitting those same genes to be used for normal development.
    1. Developmental Biology

    Epigenetic regulation of hematopoiesis by DNA methylation

    Aniket V Gore et al.
    Methylation of a key transcription factor gene by a de novo DNA methyltransferase assures the maintenance of hematopoietic stem cell fate.
    1. Cancer Biology

    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer

    SungEun Kim et al.
    Pharmacologic inhibition of DNA methylation restrains the growth of urothelial carcinoma by subtype conversion through heightened stromal Hedgehog pathway activity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart et al.
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    1. Chromosomes and Gene Expression

    Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

    Jiyong Wang et al.
    Redundant pathways prevent heterochromatin spreading and ectopic heterochromatin assembly; and plasticity of heterochromatin assembly allows cells to adapt to heterochromatin stress.