133 results found
    1. Human Biology and Medicine
    2. Neuroscience

    MRI: Searching for epilepsy’s crystal ball

    Olli Gröhn, Alejandra Sierra
    Multi-modal MRI techniques have identified biomarkers that could help to predict whether someone will develop epilepsy.
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    1. Human Biology and Medicine
    2. Neuroscience

    Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

    Achira Roy et al.
    Acute one-hour treatment of Pik3ca mutant mice with a novel anti-epilepsy drug suppresses seizures despite continued developmental brain dysmorphology, promising a new therapeutic strategy for patients with intractable pediatric epilepsy.
    1. Human Biology and Medicine
    2. Neuroscience

    Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy

    Philipp Janz et al.
    Non-invasive imaging of hippocampal neurodegeneration and structural reorganization during epileptogenesis allows the prediction of disease severity in mesial temporal lobe epilepsy, which may facilitate the early pharmacological intervention before seizure onset.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy

    Sharon R Cooper et al.
    Structural and binding studies provide insight into the molecular mechanism of protocadherin-19-mediated adhesion and into the biochemical basis of neurodevelopmental disease.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Taesun Eom et al.
    The HITS-CLIP sequencing method is used to demonstrate that cryptic exons can detect messenger RNA that contains nonsense mutations, and then cause this RNA to decay, which shows that these exons are involved in maintaining the electrical balance of neurons and, possibly, preventing epilepsy.
    1. Cell Biology
    2. Neuroscience

    The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

    Shawn McClelland et al.
    Uncovering the mechanisms by which the transcription factor NRSF contributes to the development of epilepsy reveals that the regulation of gene expression by transcription factors in the brain is more finely-tuned than previously thought.
    1. Cell Biology
    2. Neuroscience

    KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring

    Noriko Homma et al.
    Postnatal KIF2A is a key regulator for axon/dendrite determination of developing dentate granule cells, and its loss developed apical axons in dentate molecular layer, broke hippocampal wiring, and induced temporal lobe epilepsy.
    1. Neuroscience

    BAD and KATP channels regulate neuron excitability and epileptiform activity

    Juan Ramón Martínez-François et al.
    Altered activity of ATP-sensitive K+ channels underlies the metabolic seizure resistance produced by genetic manipulation of the BAD protein in mice.
    1. Neuroscience

    Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent

    Jordan S Farrell et al.
    Local tissue hypoxia follows seizures, is responsible for postictal behavioural dysfunction rather than the seizures per se and can be treated.

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