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Computational and Systems Biology
A taxonomy of seizure dynamotypes
Maria Luisa Saggio et al.
Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.
Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior
Thomas K Creson et al.
Severe neurodevelopmental disorder risk gene functions are retained into adulthood and they contribute to disease phenotypes, indicating that these patients may respond to treatments throughout life.
Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent
Jordan S Farrell et al.
Local tissue hypoxia follows seizures, is responsible for postictal behavioural dysfunction rather than the seizures per se and can be treated.
A deleterious Na
1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
Yishan Sun et al.
A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
Correction: Measurements and models of electric fields in the
human brain during transcranial electric stimulation
Yu Huang et al.
Neuromodulation: Transcranial electric stimulation seen from within the brain
Angel V Peterchev
Computer models can make transcranial electric stimulation a better tool for research and therapy.
Human Intelligence: What single neurons can tell us
Elaine N Miller, Chet C Sherwood
IQ scores are correlated with the morphology and activity of certain neurons in the human temporal cortex.
Neuropathic Pain: The pros and cons of degeneracy
Jean-Marc Goaillard, Martial A Dufour
Structural Biology and Molecular Biophysics
Ion Channels: Exploiting natural regulation
Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .
Living Science: The humanity of science
Indira M Raman
Science can provide cures and improve health, and it can also make us more humane.
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