361 results found
    1. Evolutionary Biology

    The landscape of coadaptation in Vibrio parahaemolyticus

    Yujun Cui et al.
    The first overview of fitness interactions within a species provides information how genetic interactions and ecology combine together to determine trait evolution.
    1. Chromosomes and Gene Expression
    2. Biochemistry and Chemical Biology

    Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex

    Bilge Argunhan et al.
    The intrinsically disordered N-terminus of Sfr1 contains two Rad51 binding sites that facilitate Rad51 filament stabilization and ATPase stimulation by the Swi5-Sfr1 complex, leading to efficient Rad51-driven strand exchange.
    1. Genetics and Genomics

    Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

    Nicholas Sciascia et al.
    Analysis of genome integrity in primary murine B-cells reveals how depleting 26S proteasome activity enhanced cell survival following treatment with topoisomerase poisons.
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Neuroscience

    A Toll-receptor map underlies structural brain plasticity

    Guiyi Li et al.
    Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.
    1. Developmental Biology

    Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

    Jiangnan Luo et al.
    Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
    1. Developmental Biology

    Etv transcription factors functionally diverge from their upstream FGF signaling in lens development

    Ankur Garg et al.
    The FGF-induced Etv transcription factors operate outside the confines of upstream signaling in lens development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

    Marco Fumasoni, Andrew W Murray
    Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Comprehensive fitness maps of Hsp90 show widespread environmental dependence

    Julia M Flynn et al.
    Environmental conditions strongly impact the fitness effects of Hsp90, resulting in the selection of Hsp90 sequences in nature that are robust to a variety of stressful conditions.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

    Gordana Wutz et al.
    CTCF protects cohesinSTAG1 from WAPL.

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