Autonomous patterns of cell contraction in the context of localized apical extracellular matrix constraints specify tissue stresses that reshape the wing epithelium.
The integrated quantification of spontaneous dynamic cell-cell force transmissions at both multi-cellular and subcellular scales enables spatiotemporal correlations of stress distribution with biomolecules in small cell clusters.
The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.
Clonal tracing in vivo and quantitative modeling in silico reveal a unique mode of tissue growth and structural remodeling of the biliary system, providing an insight into the cellular basis for robust liver regeneration.
Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
A computational framework called TissueMiner, complete with tutorials, will allow a wide range of users to perform quantitative multiscale analysis of tissue morphogenesis.
Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
