166 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bile salt receptor complex activates a pathogenic type III secretion system

    Peng Li, Giomar Rivera-Cancel ... Kim Orth
    Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.
    1. Cell Biology
    2. Physics of Living Systems

    De novo identification of universal cell mechanics gene signatures

    Marta Urbanska, Yan Ge ... Jochen Guck
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cell Biology

    Global analysis of contact-dependent human-to-mouse intercellular mRNA and lncRNA transfer in cell culture

    Sandipan Dasgupta, Daniella Y Dayagi ... Jeffrey E Gerst
    The RNA transferome comprises full-length mRNAs and lncRNAs that undergo non-selective and expression-dependent transfer between mammalian cells in culture via actin-based tunneling nanotubes.
    1. Cell Biology

    Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

    Milos Galic, Feng-Chiao Tsai ... Tobias Meyer
    Local inward plasma membrane deformations caused by actomyosin-dependent contraction trigger the dynamic recruitment of a curvature-sensitive actin-regulatory protein, which represents a receptor-independent auto-regulatory mechanism to control local actin polymerization dynamics at the plasma membrane.
    1. Cell Biology

    Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength

    Eike K Mahlandt, Sebastián Palacios Martínez ... Joachim Goedhart
    Optogenetic activation of Rho GTPases provides spatiotemporal control over endothelial cell shape and enables control over endothelial barrier function by manipulating the cell-cell overlap with blue light.
    1. Developmental Biology

    Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

    Zoe F Mann, Héctor Gálvez ... Nicolas Daudet
    A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.
    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai, Aurelie Bertin ... Patricia Bassereau
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Developmental Biology

    Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase

    Frédéric Bonnet, Angie Molina ... Eric Agius
    The cell cycle phosphatase CDC25B controls cell cycle progression and neurogenesis through independent pathways.
    1. Computational and Systems Biology
    2. Developmental Biology

    Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells

    Yelena Y Bernadskaya, Haicen Yue ... Alex Mogilner
    The migrating pair of cardiac progenitors in the chordate Ciona robusta is the simplest possible supracellular cell collective whose organization helps them overcome resistance from surrounding embryonic tissues during cell migration.

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