473 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development

    Amy Reilein et al.
    Somatic stem and niche cells in the Drosophila ovary develop from common precursors through regulated proliferative expansion, followed by acquisition of position-specific behaviors, rather than through rigid early specification events.
    1. Developmental Biology
    2. Neuroscience

    Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

    Tania Moreno-Mármol et al.
    Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
    1. Cell Biology

    Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons

    Adria Razzauti, Patrick Laurent
    Disposal of ciliary proteins via ectosomes budding from cilia tip or cilia base acts as a safeguard mechanism when cilia trafficking functions are impaired.
    1. Developmental Biology

    Cell-to-cell heterogeneity in Sox2 and Bra expression guides progenitor motility and destiny

    Michèle Romanos et al.
    Spatial variations of transcription factor expression regulate the choice of progenitors to stay in their niche or to migrate into neural and mesodermal tissues.
    1. Developmental Biology

    Y chromosome functions in mammalian spermatogenesis

    Jeremie Subrini, James Turner
    The mammalian Y chromosome has become specialised for male fertility, but exact functions of individual Y genes remain poorly understood, a knowledge gap that new approaches can bridge.
    1. Developmental Biology

    Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

    Konstantinos Gkatzis et al.
    A serum-free organotypic culture model of mouse lung epithelial progenitors was developed and used to screen WNT modulators for regulators of epithelial differentiation.
    1. Cell Biology
    2. Physics of Living Systems

    Autonomous clocks that regulate organelle biogenesis, cytoskeletal organization, and intracellular dynamics

    Mohammad Mofatteh et al.
    Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but have evolved to run independently to regulate different cellular events.
    1. Physics of Living Systems

    Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

    Tianfa Xie et al.
    Radial alignment in confined cell monolayers with isotropic actin network is found to be mediated by the condensation tendency and tissue-scale actin gradient.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle et al.
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.

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