Identification of heterogenous cranial neural crest (CNC)-derived cell populations and their roles in guiding craniofacial muscle development through cell-cell interactions.
A novel role of endosomal machineries retromer and ESCRT in membrane delivery of Drosophila septate junction components is required for maintenance of junction integrity and epithelial barrier function.
Muscle fiber growth during development is controlled by the Hippo pathway that links the assembly state of the contractile sarcomeres with the transcriptional state of the sarcomeric genes.
Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.
The immune Synergistic/Antagonistic Interaction Learner (iSAIL) resource has the capacity to generate insight into combinatorial immunity, help guide hypothesis generation and further experimentation relevant to basic research and drug therapeutics.
Teeth and dermal odontodes diverge from the same set of founder odontodes, demonstrating they are modified subsets of the same system, and both oral and dermal epithelial have patterning capacity.
Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
Spatially and temporally patterned activation of the small GTPase Rho1 indicates that ventral-specific factors contribute to cell- and tissue-level behaviors during ventral furrow formation, the first step in Drosophila gastrulation.