1,382 results found
    1. Stem Cells and Regenerative Medicine

    The follicle epithelium in the Drosophila ovary is maintained by a small number of stem cells

    Jocelyne Fadiga, Todd G Nystul
    Just 2-4 follicle stem cells maintain each follicle epithelium in the Drosophila ovary, and they reside within a single ring at the anterior edge of the tissue.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells

    María Inés Pérez Millán et al.
    The transcription factor PROP1 controls a genetic network that drives pituitary stem cells to undergo an epithelial-to-mesenchymal-like transition and differentiate.
    1. Stem Cells and Regenerative Medicine

    Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

    Aiguo Tian, Jin Jiang
    The niche signal that ensures stem cells self-renew appropriately has been identified in the midgut of Drosophila.
    1. Computational and Systems Biology
    2. Developmental Biology

    Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish

    Erika Tsingos et al.
    3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco et al.
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak et al.
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit et al.
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Stem Cells and Regenerative Medicine

    A mex3 homolog is required for differentiation during planarian stem cell lineage development

    Shu Jun Zhu et al.
    The planarian mex3-1 gene is required for non-stem cell fates and suppresses a stem cell fate in differentiating cells.
    1. Cell Biology
    2. Developmental Biology

    Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis

    Preetish Kadur Lakshminarasimha Murthy et al.
    Fringe proteins regulate Notch pathway differentially in the stem cell zone and progenitor compartment of the mouse intestinal epithelium to promote homeostasis.

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