900 results found
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption

    Paolo De Los Rios, Alessandro Barducci
    ATP consumption enables chaperones to exploit the different kinetic properties of their conformational states to exhibit a non-equilibrium affinity for their substrates that is orders of magnitude higher than its equilibrium value.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The dimerization equilibrium of a ClC Cl/H+ antiporter in lipid bilayers

    Rahul Chadda et al.
    Measuring the equilibrium dimerization of a polytopic membrane protein in lipid bilayers forms the basis of a new system for studying the physical forces that stabilize membrane protein association in membranes.
    1. Developmental Biology

    Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors

    Bama Charan Mondal et al.
    The THAP-domain protein Bip1, along with other proteins Nup98 and RpS8, controls the expression of the protein Pvr, a critical non-cell-autonomous regulator of Drosophila blood progenitor maintenance.
    1. Structural Biology and Molecular Biophysics

    Exploring conformational equilibria of a heterodimeric ABC transporter

    M Hadi Timachi et al.
    A heterodimeric exporter exhibits conformational equilibria in the presence of nucleotides, suggesting a unified mechanistic model for the conformational cycle of ABC exporters.
    1. Computational and Systems Biology
    2. Neuroscience

    Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

    Yanxian Lin et al.
    Liquid-liquid phase separation of tau is demonstrated to be an equilibrium state, stable only within a narrow range near physiological conditions, and thus has the capacity to regulate biological processes.
    1. Cell Biology

    Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

    Lydia WT Cheung et al.
    The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.
    1. Structural Biology and Molecular Biophysics

    Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

    Lukasz Wieteska et al.
    The molecular chaperone BIP from the endoplasmic reticulum is fine-tuned postranslationally through the thermodynamic and kinetic alterations in its conformational ensemble of functionally and structurally distinct physiological forms.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle et al.
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin et al.
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Structural Biology and Molecular Biophysics

    A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

    Anne K Schuetz, Lewis E Kay
    Point mutations in a ubiquitous human ATPase called p97/VCP deregulate inter-domain communication, resulting in impaired binding of an adaptor that recruits p97 to endosomal pathways and leading to a degenerative disease of bone, muscle and neurons.

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