Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.

Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.

Structural and functional analyses reveal the general mechanism of activation of the thrombopoietin receptor and unravel the critical role of W515.

Experimentation on patient biopsies, cell culture, and xenograft models demonstrates involvement of ErbB signaling and fibroblasts in lesion growth, implying that targeting of both stromal and endothelial cells could be a beneficial treatment strategy for patients with venous lesions.