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Apelin signaling-dependent endocardial protrusions promote cardiac trabeculation through Nrg/ErbB/Erk signaling in zebrafish.

The intracellular SOCS5 protein has a unique and key role in restraining influenza A infection by regulating epidermal growth factor receptor signaling in airway epithelial cells.

Extracellular matrix signaling constitutively regulates cerebral blood flow in both physiological and pathological settings.

In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.

pYtags are novel biosensors that can be used to measure the activity of a receptor tyrosine kinase of interest in live cells with high spatiotemporal resolution and are applied to reveal rapid activity dynamics of EGFR/ErbB2 signaling.

Cryo-EM analysis of full-length human epidermal growth factor receptor provides a molecular explanation for how ligand-induced differential effect in the ligand-binding extracellular module tunes the transmembrane signaling mediated by epidermal growth factor receptor.

Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.

Kidney-specific TFEB overexpression in transgenic mice closely recapitulates features observed in both TFEB- and TFE3-mediated human kidney tumors.

Astrocyte signaling can activate the firing of gonadotropin-releasing hormone neurons and stimulate hormone release.

Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.