Live-cell imaging shows that replication-independent specialized polymerase action is a consequence of lesion processing via NER and impacts cellular survival under stress outside replicative phases of the cell cycle.

Competing DNA polymerases at the DNA sliding clamp are revealed by single-molecule co-localization studies.

The details of how the enzyme DNA polymerase α initiates the polymerization of nucleotides in DNA replication, a critical step in the synthesis of new chromosomal DNA, have been revealed in atomic detail.

Fundamental details of the rate and molecular spectrum of transcript errors were revealed in four bacterial species, providing novel insights into transcriptional fidelity and RNA quality-control in prokaryotes.

DNA synthesis by DNA polymerase V is regulated by an intrinsic DNA-dependent ATPase activity which has not been observed for any other polymerase.

Improved chemical, molecular biology, and computational approaches establish an optimized method for accurate and precise quantification of tRNA expression, modifications, and aminoacylation.

A single human cell makes 10-100 transcriptional errors per second; these errors affect splicing and may influence the evolution of coding sequences.

Despite the virus' error prone polymerase, influenza virus antigenic evolution is rare, even in previously immune hosts, virus replication occurs before producing new antibodies.

Genetic and biochemical analyses reveal an important role for the translesion DNA polymerase DinB2 in mycobacterial mutagenesis, including in the insertion/deletion events that are an increasingly recognized type of diversity in Mycobacterium tuberculosis genomes.

Polymerase θ is among the most proficient terminal transferases known and switches between three different mechanisms of terminal transferase activity.