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    1. Medicine

    Ocular biomarker profiling after complement factor I gene therapy in geographic atrophy secondary to age-related macular degeneration

    Thomas M Hallam, Emanuela Gardenal ... Amy V Jones
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

    Timothy J Abreo, Emma C Thompson ... Edward C Cooper
    A single amino acid change in a neuronal ion channel called KCNQ2 blocks ion flow, prevents protein localization on axons, and results in severe epilepsy and slowed neurological development.
    1. Neuroscience

    Why the brown ghost chirps at night

    Livio Oboti, Federico Pedraja ... Rüdiger Krahe
    Electric signals produced by weakly electric gymnotiform fish, long seen as communication attempts, may also serve to localize conspecifics, revealing a distinct functional role.
    1. Neuroscience

    Activity-dependent lateral inhibition enables the synchronization of olfactory bulb projection neurons

    Tal Dalal, Rafi Haddad
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Contributions of associative and non-associative learning to the dynamics of defensive ethograms

    Quan-Son Eric Le, Daniel Hereford ... Jonathan P Fadok
    Associative and non-associative learning mechanisms summate to produce robust and complex conditioned behavior profiles, opening new avenues to in-depth investigations of defensive responses and threat evaluation.
    1. Medicine

    Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial

    Feilin Cao, Zhaosheng Ma ... Shifen Huang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Stem Cells and Regenerative Medicine

    Dynamic tracking of native precursors in adult mice

    Suying Liu, Sarah E Adams ... Peter Kurre
    A revised analytical framework grounded in the principle of binomial distribution captures the full clonality and dynamic shifts of hematopoiesis throughout ontogeny.
    1. Ecology
    2. Physics of Living Systems

    Colony demographics shape nest construction in ants

    Harikrishnan Rajendran, Roi Weinberger ... Ofer Feinerman
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct

    Giordano de Guglielmo, Lieselot Carrette ... Olivier George
    Genetically diverse rats reveal a single underlying construct linking key addiction-like behaviors, challenging compulsivity as an independent measure, and offering a new perspective on vulnerability and resilience to addiction.