4,619 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

    Michael Chas Sumner et al.
    Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart et al.
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao et al.
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
  1. city map at night

    Rebuilding foundations: Making Open Knowledge Maps future-proof

    How the Open Knowledge Maps team tackled technical debt, while building the foundations for new promising features.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Neuroscience

    Shape-invariant encoding of dynamic primate facial expressions in human perception

    Nick Taubert et al.
    Contrasting with neural network theories, a study of the cross-species perception of dynamic faces with highly realistic human and monkey avatars reveals independent perceptual encoding of facial shape and expression.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle et al.
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu et al.
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Neuroscience

    Corticothalamic gating of population auditory thalamocortical transmission in mouse

    Baher A Ibrahim et al.
    Sensory stimulation produces stochastic population responses in the cortex that are governed by layer 6 cortico-reticular projections that modulate thalamic synchrony.

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