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    1. Cell Biology
    2. Developmental Biology

    Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

    Jaydeep Sidhaye, Caren Norden
    Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
    1. Physics of Living Systems
    2. Developmental Biology

    Unified quantitative characterization of epithelial tissue development

    Boris Guirao et al.
    A new approach measures the respective participations of elementary cell behaviors – such as cell division, intercalation, shape change and death – in the shaping of animal tissues.
    1. Neuroscience

    A genetic basis for molecular asymmetry at vertebrate electrical synapses

    Adam C Miller et al.
    Electrical synapses are neuronal, gap-junction-based connections found throughout the nervous system that, in the escape circuit of zebrafish, are composed of molecularly distinct pre- and postsynaptic junction forming proteins that are required for behavioral performance.
    1. Neuroscience

    Decoding a neural circuit controlling global animal state in C. elegans

    Patrick Laurent et al.
    Sensory neurons that monitor ambient oxygen control a cascade of responses across multiple layers of interneurons to switch the global state of the nematode C. elegans, reprogramming behavior and gene expression to enable escape from or adaptation to surface exposure.
  1. Research Culture: Framework for advancing rigorous research

    Walter J Koroshetz et al.
    Establishing a community of 'rigor champions' and building a comprehensive educational platform to teach the principles of rigorous science will help to ensure that the outputs of scientific research remain reliable and robust.
  2. Point of View: Improving on legacy conferences by moving online

    Titipat Achakulvisut et al.
    Neuromatch was an online conference that attracted around 3000 participants and offered most of the benefits of traditional conferences.
    1. Cell Biology
    2. Plant Biology

    Microscopy: Looking below the surface in plants

    Rui Wang, Anna A Dobritsa
    A new way to culture and image flowers is uncovering the processes that take place in reproductive cells buried deep in plants.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetics: A memory of longevity

    Felicity Emerson et al.
    Worms with increased levels of the epigenetic mark H3K9me2 have a longer lifespan that can be passed down to future generations.
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    1. Cell Biology
    2. Developmental Biology

    Philosophy of Biology: The analysis of living systems can generate both knowledge and illusions

    Antony M Jose
    By thinking about experimental techniques in terms of six broad approaches – perturbation, visualization, substitution, characterization, reconstitution, and simulation – researchers may be able to generate more reliable inferences.