109 results found
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates, James D Manton ... Gregory SXE Jefferis
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Microbiology and Infectious Disease

    Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

    Valérie Laroute, Catherine Beaufrand ... Muriel Cocaign-Bousquet
    Generally recognised as safe GABA-producing L. lactis strains could be considered as future therapeutic agents for the management of visceral pain and the anxious profile of IBS patients.
    1. Developmental Biology

    Single-cell profiling coupled with lineage analysis reveals vagal and sacral neural crest contributions to the developing enteric nervous system

    Jessica Jacobs-Li, Weiyi Tang ... Marianne E Bronner
    Single-cell transcriptome analysis of sacral compared with vagal neural crest-derived cells in the developing chick enteric nervous system reveals both similarities and differences between these two cell populations.
    1. Cell Biology

    SLY1 and Syntaxin 18 specify a distinct pathway for procollagen VII export from the endoplasmic reticulum

    Cristina Nogueira, Patrik Erlmann ... Vivek Malhotra
    A cross-linking screen finds proteins that interact with TANGO1 to export Procollagen VII, and suggests a new model for the secretion of these bulky cargoes that are involved in skin and bone formation.
    1. Evolutionary Biology
    2. Physics of Living Systems

    In vivo intraoral waterflow quantification reveals hidden mechanisms of suction feeding in fish

    Pauline Provini, Alexandre Brunet ... Sam Van Wassenbergh
    The integration of biplanar X-ray videos with 3D X-ray particle tracking revealed that fish use a combination of intraoral 'central jet' waterflow pattern and inertia to guide food toward the digestive tract during suction feeding.
    1. Neuroscience

    Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

    Christina E May, Julia Rosander ... Monica Dus
    Taste-dependent satiation, which induces proper cessation of feeding in mammals as well as insects, is weakened by sugar-diet-driven taste impairment in the fruit fly.
    1. Developmental Biology

    Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

    Shiri Kult, Tsviya Olender ... Elazar Zelzer
    The molecular identity of bi-fated tendon-to-bone attachment cells, which display a mixture of transcriptomes of two neighboring cell types, enables the formation of the unique transitional tissue of the enthesis.
    1. Cell Biology

    Endosomal Chemokine Receptor Signalosomes Regulate Central Mechanisms Underlying Cell Migration

    Hyunggu Hahn, Carole Daly ... Alex Rojas Bie Thomsen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Developmental Biology

    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

    Chao Chang, Sara L Banerjee ... Artur Kania
    Extracellular signals mediated by the EphB2 receptor tyrosine kinase may access the effectors of fundamental cell functions controlled by MYCBP2.
    1. Cell Biology

    PM2.5 leads to adverse pregnancy outcomes by inducing trophoblast oxidative stress and mitochondrial apoptosis via KLF9/CYP1A1 transcriptional axis

    Shuxian Li, Lingbing Li ... Xietong Wang
    Airborne PM2.5 exposure triggers oxidative stress and mitochondrial apoptosis in placental trophoblast cells via the KLF9/CYP1A1 transcriptional axis, ultimately leading to adverse pregnancy outcomes.

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