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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch

    Kotaro Sugimoto et al.
    A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones

    Heather A McCauley et al.
    A new mechanism connects the loss of TGFβ signaling with invasion and metastasis in highly malignant transition zone tumors.
    1. Developmental Biology
    2. Evolutionary Biology

    The evolutionary origin of bilaterian smooth and striated myocytes

    Thibaut Brunet et al.
    Molecular profiling of annelid myocytes reveals that the last common protostome-deuterostome ancestor already possessed a dual musculature, with visceral smooth muscles ensuring digestion and somatic striated muscles ensuring locomotion.
    1. Evolutionary Biology

    Splicing repression allows the gradual emergence of new Alu-exons in primate evolution

    Jan Attig et al.
    During evolutionary progression of Alu-exons, repressive U-tracts buffer sudden gains in 3' splice site strength and prevent inclusion of cryptic exons.
    1. Developmental Biology
    2. Human Biology and Medicine

    Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice

    Rita Carmona et al.
    Expression of the transcription factor Wt1 is required in a lateral mesoderm domain to develop the mesenchymal population required for the closure of the pleural cavities and the formation of the diaphragm.
    1. Developmental Biology

    Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

    M Lucila Scimone et al.
    Single-cell RNA sequencing identifies an adult regional gene expression map in planarian muscle that includes two FGFRL-Wnt circuits controlling head and trunk tissue pattern.
    1. Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann et al.
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    1. Developmental Biology
    2. Genetics and Genomics

    Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo

    Megan L Martik, David R McClay
    The gene regulatory network controlling directed cell migration in a sea urchin is strikingly similar to a sub-circuit for eye development in Drosophila, suggesting that ancient systems-level controls may be adapted for diverse functions in different animals.
    1. Developmental Biology
    2. Evolutionary Biology

    Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm

    Carmen Andrikou et al.
    A gene regulatory network model provides a simplified explanation of the molecular interactions that orchestrate muscle development in the sea urchin embryo.