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A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling
Ajun Geng et al.
Wnt/β-Catenin independent role of Rspo1 in physiological condition is revealed.
Structural Biology and Molecular Biophysics
Breast Cancer: How drug resistance takes shape
Rinath Jeselsohn, Myles Brown
Chromosomes and Gene Expression
The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells
Adrien Georges et al.
FOXL2 maintenance of ovarian identity is not solely due to a simple direct repression of Sox9 but to the mobilization of estrogen signalling by FOXL2.
Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction
Luhong Wang et al.
Estradiol regulates the pre-ovulatory luteinizing hormone surge through hypothalamic anteroventral periventricular kisspeptin neurons and maintains reproductive cyclicity through arcuate kisspeptin neurons in an activational manner.
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Sean W Fanning et al.
Bazedoxifene's SERD activities enable it to resist the impact of activating ESR1 mutations in breast cancer.
The Natural History of Model Organisms: The unlimited potential of the great pond snail,
István Fodor et al.
The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
Genetics and Genomics
Genome-wide Association Study: Not so benign
Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
The Natural History of Model Organisms: Planting molecular functions in an ecological context with
Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
Genetics and Genomics
Point of View: Bioengineering horizon scan 2020
Luke Kemp et al.
20 emerging issues in bioengineering that will have profound impacts on society have been identified.
Biochemistry and Chemical Biology
Bone-Targeting Drugs: From vesicle to cytosol
Michael J Rogers, Marcia A Munoz
Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
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