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    1. Developmental Biology

    A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling

    Ajun Geng et al.
    Wnt/β-Catenin independent role of Rspo1 in physiological condition is revealed.
    1. Structural Biology and Molecular Biophysics

    Breast Cancer: How drug resistance takes shape

    Rinath Jeselsohn, Myles Brown
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    1. Chromosomes and Gene Expression

    The transcription factor FOXL2 mobilizes estrogen signaling to maintain the identity of ovarian granulosa cells

    Adrien Georges et al.
    FOXL2 maintenance of ovarian identity is not solely due to a simple direct repression of Sox9 but to the mobilization of estrogen signalling by FOXL2.
    1. Neuroscience

    Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

    Luhong Wang et al.
    Estradiol regulates the pre-ovulatory luteinizing hormone surge through hypothalamic anteroventral periventricular kisspeptin neurons and maintains reproductive cyclicity through arcuate kisspeptin neurons in an activational manner.
    1. Cancer Biology

    The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

    Sean W Fanning et al.
    Bazedoxifene's SERD activities enable it to resist the impact of activating ESR1 mutations in breast cancer.
    1. Developmental Biology
    2. Neuroscience
    Pond snail illustration

    The Natural History of Model Organisms: The unlimited potential of the great pond snail, Lymnaea stagnalis

    István Fodor et al.
    The great pond snail is a multipurpose model organism and a contemporary choice for addressing a wide range of biological questions, problems and phenomena in the laboratory and the field.
    1. Genetics and Genomics

    Genome-wide Association Study: Not so benign

    Barbara Rivera
    Susceptibility to uterine fibroids, benign tumors that affect the health of many women, is linked to genes that are responsible for preserving genome integrity and promoting genitourinary development.
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    1. Ecology
    2. Plant Biology
    Arabidopsis illustration

    The Natural History of Model Organisms: Planting molecular functions in an ecological context with Arabidopsis thaliana

    Ute Krämer
    Research in molecular ecology and evolution is increasingly utilizing the model plant Arabidopsis thaliana, placing a spotlight on its natural history.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Bone-Targeting Drugs: From vesicle to cytosol

    Michael J Rogers, Marcia A Munoz
    Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
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