Browse the search results

Page 2 of 251
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

    Zhou Yu et al.
    Identification of a transporter complex comprised of SLC37A3 and ATRAID is required for nitrogen-containing bisphosphonates to enter the cytosol from lysosomes and exert their therapeutic effects on bone.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta et al.
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Neuroscience

    Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model

    Satoru M Sato, Catherine S Woolley
    Seizures stimulate estrogen synthesis in the brain and acutely inhibiting brain estrogen synthesis suppresses seizures, in both sexes, without additional interventions.
    1. Stem Cells and Regenerative Medicine

    ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

    Richard H Chapple et al.
    Estrogen is a systemic factor that promotes hematopoietic regeneration by activating the unfolded protein responses.
    1. Structural Biology and Molecular Biophysics

    Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

    Sean W Fanning et al.
    Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
    1. Medicine

    Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

    Shivani N Mann et al.
    17α-Estradiol, a life-span extending compound, signals through estrogen receptor α (ERα) in the liver and hypothalamus to elicit health benefits in a sex-specific manner.
    1. Plant Biology

    A plant chitinase controls cortical infection thread progression and nitrogen-fixing symbiosis

    Anna Malolepszy et al.
    Lotus japonicus chitinase modulates the level of rhizobial Nod factor and thereby enables cortical infection and functional symbiosis in root nodules.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals

    Markus Gressler et al.
    Elevated methionine levels, or a shortage of nitrogen or iron, induce terrein production in the fungus Aspergillus terreus.
    1. Cancer Biology

    Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

    Christopher A Natale et al.
    Driving melanoma differentiation through G protein-coupled estrogen receptor signaling decreases proliferative capacity, decreases expression of the oncodriver and stem cell marker c-Myc, and increases the effectiveness of immunotherapy.
    1. Cancer Biology

    The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

    James D Joseph et al.
    GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.