6,008 results found
    1. Neuroscience

    A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

    Brad K Hulse, Hannah Haberkern ... Vivek Jayaraman
    An analysis of the first complete synaptic resolution connectome of Drosophila's navigation circuit uncovers neural network motifs supporting broadly relevant sensorimotor computations.
    1. Genetics and Genomics

    A genetic and linguistic analysis of the admixture histories of the islands of Cabo Verde

    Romain Laurent, Zachary A Szpiech ... Paul Verdu
    The complex histories of social relationships between enslaved and non-enslaved communities and their descendants during and after the Trans-Atlantic Slave-Trade shaped the detailed genetic and linguistic histories of admixture of the islands of Cabo Verde.
    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees, Jun-Hai Yang ... Alain Karma
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
    1. Computational and Systems Biology

    Essential metabolism for a minimal cell

    Marian Breuer, Tyler M Earnest ... Zaida Luthey-Schulten
    A near-complete flux balance analysis model of a minimal cell demonstrates the high essentiality of its metabolic genes, agrees well with experimental essentiality data and suggests some further gene removals.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola, An Dau ... Jouni Takalo
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha, Alban Ordureau ... Rachel Green
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone

    Assmaa ElSheikh, Camden M Driggers ... Show-Ling Shyng
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling

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