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Genetics and Genomics
Placenta: When the past informs our future
Comparing the genes expressed at the maternal-fetal interface in different species helps to pinpoint those that contribute to a healthy pregnancy by regulating the activity of the immune system.
Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation
Ming Chen et al.
Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.
Single nuclei RNA-seq of mouse placental labyrinth development
Bryan Marsh, Robert Blelloch
A time-course of single nuclei RNA-seq of the mouse placenta identifies trophoblast subtypes and the genes, signaling events, and transcriptional networks important for their differentiation, maintenance, and function.
Antidepressants: Where ketamine and dopamine collide
David J Marcus, Michael R Bruchas
Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.
Genetics and Genomics
Circular RNA repertoires are associated with evolutionarily young transposable elements
Franziska Gruhl et al.
Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk
Juan M Vazquez, Vincent J Lynch
Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
Structural Biology and Molecular Biophysics
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication
Agnieszka Fatalska et al.
The dual functional protein, Gorab, associates with the Golgi as a dimer but as a monomer with the procentriole cartwheel protein, Sas6, to mediate centriole duplication.
Phylogenetic variation in cortical layer II immature neuron reservoir of mammals
Chiara La Rosa et al.
The higher amount of cortical immature neurons in brains with expanded neocortices may represent a reservoir of young cells for mammals with reduced neurogenesis.
Chromosomes and Gene Expression
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation
Ava C Carter et al.
A long noncoding RNA uses viral mimicry to achieve developmental gene silencing across a chromosome.
Retinal oxygen supply shaped the functional evolution of the vertebrate eye
Christian Damsgaard et al.
Multiple respiratory and vascular mechanisms have recurrently evolved across the vertebrates to alleviate the oxygen diffusion limitations inherent to the morphology of the retina.
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