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    1. Developmental Biology
    2. Evolutionary Biology

    Molecular insights into the origin of the Hox-TALE patterning system

    Bruno Hudry et al.
    Interactions between Hox and TALE genes, which generate bilaterally symmetrical body plans, originated in early multicellular animals.
    1. Cell Biology
    2. Developmental Biology

    Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome

    Katherine Young Bezold Lamm et al.
    Loss of Inverted Formin-2 impairs intracellular trafficking and trophoblast invasion, resulting in maternal hypertension and intrauterine growth restriction, which represents a novel model of impaired placental invasion that encompasses critical aspects of the great obstetrical syndromes.
    1. Medicine

    Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice

    Chelsea Hepler et al.
    Genetic inactivation of the transcription factor, Zfp423, in visceral white adipocyte precursors leads to the formation of thermogenic adipocytes in visceral fat depots and improves insulin sensitivity in obese mice.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey et al.
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak et al.
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera et al.
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Ecology

    Implications of being born late in the active season for growth, fattening, torpor use, winter survival and fecundity

    Britta Mahlert et al.
    Being born late in the active season is associated with a fast life history in a hibernating species, the garden dormouse (Eliomys quercinus).
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long et al.
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Neuroscience

    Cold-induced hyperphagia requires AgRP neuron activation in mice

    Jennifer D Deem et al.
    A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development

    Jennifer Hampton Hill et al.
    A previously undescribed protein produced by certain resident intestinal bacteria induces zebrafish pancreatic beta cell expansion.