12,071 results found
    1. Evolutionary Biology

    Digital restoration of the pectoral girdles of two Early Cretaceous birds and implications for early-flight evolution

    Shiying Wang, Yubo Ma ... Xing Xu
    New digital restorations indicate that the structure and function of the shoulder joint were highly variable among Early Cretaceous birds, with such key features as the configuration of the triosseal canal and the nature of scapula-coracoid articulation showing considerable diversity.
    1. Developmental Biology

    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

    Tingwei Guo, Xia Han ... Yang Chai
    A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation

    Xiaofei Bai, Jeff Bouffard ... Andy Golden
    Depletion of the mechanosensitive ion channel PEZO-1 in C. elegans disrupts the sheath and spermathecae cells to disrupt oocyte ovulation, resulting in crushed oocytes.
    1. Cell Biology
    2. Genetics and Genomics

    Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

    Anthony J Veltri, Karole N D'Orazio ... Rachel Green
    Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt, Matthew Robert Geoffrey Russell ... Moritz Treeck
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski, James L Mueller ... Julie Zikherman
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier, Anna Posfai ... Ned S Wingreen
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Histone H1 prevents non-CG methylation-mediated small RNA biogenesis in Arabidopsis heterochromatin

    Jaemyung Choi, David B Lyons, Daniel Zilberman
    Linker histone H1 and cytosine DNA methylation in contexts other than CG explain patterns of 24 nucleotide small RNA biogenesis in Arabidopsis thaliana.
    1. Immunology and Inflammation

    SPOP targets the immune transcription factor IRF1 for proteasomal degradation

    Irene Schwartz, Milica Vunjak ... Gijs A Versteeg
    SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
    1. Evolutionary Biology

    Evolution of sexual conflict in scorpionflies

    Agnieszka Soszyńska-Maj, Ewa Krzemińska ... Wiesław Krzemiński
    The fossil record of abdominal modifications in male scorpionflies documents a relatively late evolution of oppressive behaviour toward a female during mating and suggest degree of sexual coercion greater in Eocene than in any other known scorpionfly, extinct or extant.

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