12,071 results found
    1. Cell Biology
    2. Developmental Biology

    Science Forum: Imaging methods are vastly underreported in biomedical research

    Guillermo Marqués, Thomas Pengo, Mark A Sanders
    The poor reporting of imaging methods in the scientific literature is hindering the evaluation and replication of biomedical research.
    1. Neuroscience

    Evaluation of surface-based hippocampal registration using ground-truth subfield definitions

    Jordan DeKraker, Nicola Palomero-Gallagher ... Alan C Evans
    Surface-based registration of the folded or unfolded human hippocampus achieves subfield alignment to within approximately 0.5 mm.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

    Anastasia O Smirnova, Anna M Miroshnichenkova ... Alexander Komkov
    A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.
    1. Medicine
    2. Epidemiology and Global Health

    A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

    Victoria T Hunniford, Agnes Grudniewicz ... Manoj M Lalu
    Preclinical multilaboratory studies are a robust method to assess promising interventions.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil

    Rachel Lowe, Caio AS Coelho ... Xavier Rodó
    The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Improved T cell receptor antigen pairing through data-driven filtering of sequencing information from single cells

    Helle Rus Povlsen, Amalie Kai Bentzen ... Morten Nielsen
    A bioinformatics approach shows how to reduce noise in single-cell TCR-pMHC specificity data while retaining sensitivity toward cross-binding events to facilitate investigation of the rules governing TCR-pMHC binding.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Artificial selection methods from evolutionary computing show promise for directed evolution of microbes

    Alexander Lalejini, Emily Dolson ... Luis Zaman
    Multiobjective artificial selection methods from evolutionary computing show promise for improving directed evolution outcomes when selecting for multiple traits of interest.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a live birth prediction model for evaluating human blastocysts from a retrospective study

    Hang Liu, Zhuoran Zhang ... Yu Sun
    The inclusion of the patient couple's clinical features along with blastocyst images increases live birth prediction accuracy.
    1. Medicine

    Trio-based whole exome sequencing in patients with suspected sporadic inborn errors of immunity: A retrospective cohort study

    Anne Hebert, Annet Simons ... Caspar I van der Made
    Systematic assessment of de novo variants in patients with sporadic inborn errors of immunity led to the identification of promising candidate variants in known and novel immune genes, supporting its implementation in the routine diagnostic evaluation of these patients.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

    Oliver Stirrup, Joseph Hughes ... Judith Breuer
    Epidemiological and viral sequence data can be combined to provide standardised feedback on cases of hospital onset COVID-19 infection that would be useful for infection prevention and control.

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