Method NEAdriver employs knowledge from global networks to predict novel cancer driver genes in an individualized manner, which is done by accounting for mutations’ co-occurrence in each tumor genome and rigorous statistical evaluation.
The San Francisco Declaration on Research Assessment (DORA) has developed a new tool called SPACE to support universities and institutions working to improve the assessment of research.
Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
William HK Schilling, Podjanee Jittamala ... Nicholas J White
Pharmacometric evaluation of viral clearance rates based on frequent oropharyngeal sampling is a highly efficient and well-tolerated method of assessing and comparing SARS-CoV-2 antiviral therapeutics in vivo.
The Time Point Selection (or TPS) method is a general protocol for determining sampling rates for high throughout time series biological studies, that is efficient, cheap, scalable and works well for several different types of molecular data.
The proportional recovery rule, an apparently simple model that nonetheless requires careful statistical treatment, remains an important biological and predictive framework for stroke recovery.
Heiko H Schütt, Alexander D Kipnis ... Nikolaus Kriegeskorte
New methods for statistical inference in representational similarity analysis were developed, tested thoroughly, and are made available in an open-source Python toolbox.
Integrating multiple protein language models using protein geometric graphs can dramatically improve the model performance for predicting the contacting residue pairs between interacting proteins.
Methods for video analysis of behaving animals are described, with guidance provided on setting up the methods in a research laboratory and best practices for experimenters and developers.
Sofie Louise Valk, Philipp Kanske ... Tania Singer
Training attention-mindfulness, emotion-motivational, and social cognitive skills over the course of 3 months alters brain functional and microstructural organization as a function of training content.
