863 results found
    1. Genomics and Evolutionary Biology

    On the mechanistic nature of epistasis in a canonical cis-regulatory element

    Mato Lagator et al
    Thermodynamic framework accurately predicts the sign of epistasis and its environment dependence for a canonical cis-regulatory element.
    Research Article Updated
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    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Population scale mapping of transposable element diversity reveals links to gene regulation and epigenomic variation

    Tim Stuart et al
    Fine mapping of transposable element presence/absence variation amongst 216 Arabidopsis strains uncovers widespread novel genetic diversity that underlies differences in transcription and DNA methylation patterns.
    Research Article Updated
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    1. Biochemistry
    2. Microbiology and Infectious Disease

    Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

    Zhong-Yu Liu et al
    A conserved element in the flavivirus genomic 5′ terminus switches its conformation in response to long-range RNA interactions, and thereby regulates the dynamic recruitment of viral replicase for efficient viral RNA replication.
    Research Article Updated
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    1. Genes and Chromosomes

    Transcription dynamically patterns the meiotic chromosome-axis interface

    Xiaoji Sun et al
    Distributed cohesin rings flexibly tether the axial element structure of meiotic chromosomes to the underlying chromatin to readily accommodate ongoing transcription.
    Research Article
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    1. Biochemistry
    2. Microbiology and Infectious Disease

    RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

    Bhargavi Jayaraman et al
    A pliable hydrophobic interface in the HIV-1 Rev protein enables assembly of diverse oligomeric structures, guided by the RRE scaffold present in HIV-1 mRNAs.
    Research Article Updated
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    1. Biochemistry
    2. Biophysics and Structural Biology

    A conserved MCM single-stranded DNA binding element is essential for replication initiation

    Clifford A Froelich et al
    The crystal structure of the MCM helicase bound to single-stranded DNA reveals a binding motif that is critical for cell viability, helicase activation and DNA replication.
    Research Article
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    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

    Hamish W King, Robert J Klose
    The chromatin remodeller BRG1 is recruited to pluripotency-associated gene regulatory elements by the pioneer transcription factor OCT4 to support further transcription factor binding and gene regulation.
    Research Article Updated
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    1. Genes and Chromosomes

    The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivo

    Steven Henikoff et al
    A stable tetrameric nucleosome occupies the central segment of each ∼120-bp budding yeast centromere in two rotational phases of both reflectional orientations in vivo.
    Research Article
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    1. Plant Biology

    Long Distance Transport: Under pressure

    Ulrich Z Hammes
    Insight
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    1. Plant Biology

    Circadian Rhythms: Time for a change

    Sabrina E Sanchez, Marcelo J Yanovsky
    Insight
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf

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