The patterns of chromatin architecture that underlie the initial embryonic cell fate decisions are established during a period of intense cell cycle activity, and these patterns are stably maintained even in highly condensed mitotic chromatin.
Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
Independently gating ion channels typically act fast within milliseconds, but cooperative interactions within a cluster of channels allow for a memory of previous electrical activity for several seconds.
Folding and unfolding pathways are described for a ribosome-binding 3' cap-independent translation enhancer at the center of a conformational rearrangement that is implicated in the transition from translation to replication of an RNA virus.
Type I interferon signaling protects cells from the loss of epigenetic integrity, since it is activated in cells in response to accumulation of transcripts originating from normally silenced heterochromatin, caused by small-molecule-mediated nucleosome unfolding.
The identification of a single-CD4 bound asymmetric HIV-1 Envelope trimer intermediate provides new mechanistic insights into the activation of Envelope for fusion, and highlights the importance of asymmetry in biology.