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Mesoscopic-scale functional networks in the primate amygdala
Jeremiah K Morrow et al.
Multivariate data decomposition applied to local field potentials recorded from the primate amygdala revealed simultaneously active and functionally distinct networks, defined by anatomical boundaries between the nuclei.
The manifold actions of signaling peptides on subcellular dynamics of a receptor specify stomatal cell fate
Xingyun Qi et al.
A binary cell fate decision to be or not to be stomata is regulated by multiple peptide ligands, each triggering a unique subcellular dynamics of their shared receptor.
Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
Víctor J López-Madrona et al.
Integration and segregation of information of memory and sensory in the hippocampus could be achieved by the coordination of distinct theta-gamma coding frameworks.
Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers
Özgür Genç et al.
Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
Fatty acid β-oxidation is required for the differentiation of larval hematopoietic progenitors in
Satish Kumar Tiwari et al.
Genetic and molecular analyses reveal the decisive role of fatty acid oxidation (FAO) acting downstream to the ROS-JNK circuit essential for hemocyte progenitor differentiation in
Microbiology and Infectious Disease
Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides
Giancarlo Noe Bruni, Joel M Kralj
Aminoglycosides are a class of antibiotics that can kill
by building up internal voltage through disrupting the normal consumption of ATP.
Genetics and Genomics
Alternative polyadenylation mediates genetic regulation of gene expression
Briana E Mittleman et al.
Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.
Chromosomes and Gene Expression
Translational initiation in
occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing
Kazuki Saito et al.
ribosomes incapable of base-pairing with the Shine-Dalgarno sequence are still selective for annotated start sites, indicating these sites are hard-wired for initiation by other mRNA features.
Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse
Céline Portal et al.
Primary cilia of neural crest-derived cells mediate Indian hedgehog-induced signal transduction in the periocular mesenchyme and are required for normal anterior segment development.
Noninvasive quantification of axon radii using diffusion MRI
Jelle Veraart et al.
Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
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