4,068 results found
    1. Microbiology and Infectious Disease

    Severe infections emerge from commensal bacteria by adaptive evolution

    Bernadette C Young et al.
    Life-threatening S. aureus infections emerge from commensal nose bacteria in association with repeatable adaptive evolution.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms

    Jian Ming Khor, Charles A Ettensohn
    A gene duplication event has permitted the functional specialization of a homeodomain transcription factor through changes in exon-intron organization and these changes have supported the evolution of a major, phylum-level morphological novelty.
    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    Using evolution to generate sustainable malaria control with spatial repellents

    Penelope Anne Lynch, Mike Boots
    The evolution of insecticide-avoidance behaviour can be used to generate new spatial repellents to keep malaria vectors out of homes.
    1. Biochemistry
    2. Genomics and Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach et al.
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.
    1. Computational and Systems Biology
    2. Genomics and Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al.
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    1. Genomics and Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson et al.
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
    1. Biophysics and Structural Biology
    2. Genomics and Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al.
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong et al.
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al.
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    1. Genes and Chromosomes

    Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes

    Yanxiang Ni et al.
    Molecular beacon based FISH shows the capability of visualizing a 2.5 kb non-repetitive genomic DNA sequence in situ in human or mouse nuclear genome at super resolution.

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