1,011 results found
    1. Genomics and Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson et al
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.
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    1. Epidemiology and Global Health
    2. Genomics and Evolutionary Biology

    Using evolution to generate sustainable malaria control with spatial repellents

    Penelope Anne Lynch, Mike Boots
    The evolution of insecticide-avoidance behaviour can be used to generate new spatial repellents to keep malaria vectors out of homes.
    Research Article
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    1. Biochemistry
    2. Genomics and Evolutionary Biology

    Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

    Miriam Kaltenbach et al
    Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.
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    1. Computational and Systems Biology
    2. Genomics and Evolutionary Biology

    Expression noise facilitates the evolution of gene regulation

    Luise Wolf et al
    In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
    Research Article
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    1. Biophysics and Structural Biology
    2. Genomics and Evolutionary Biology

    An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases

    Jeffrey I Boucher et al
    The convergent evolution of unusually strict substrate specificity in apicomplexan LDHs arose by classic neofunctionalization of a duplicated MDH gene via few mutations of large effect.
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Stability-mediated epistasis constrains the evolution of an influenza protein

    Lizhi Ian Gong et al
    Some of the mutations that occur during influenza evolution can only be tolerated in conjunction with other mutations that increase the stability of a viral protein.
    Research Article
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    1. Genomics and Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.
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    1. Genomics and Evolutionary Biology
    2. Plant Biology

    The role of photorespiration during the evolution of C4 photosynthesis in the genus Flaveria

    Julia Mallmann et al
    Metabolic exaptation of an anaplerotic nitrogen cycle between bundle sheath and mesophyll cells may explain the remarkably frequent convergent evolution of C4 photosynthesis.
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    1. Genomics and Evolutionary Biology

    Evolution of insect olfactory receptors

    Christine Missbach et al
    Insect specific olfactory receptors are not an adaptation to a terrestrial insect lifestyle, but evolved later in insect evolution.
    Research Article
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    1. Cell Biology
    2. Genomics and Evolutionary Biology

    tRNA genes rapidly change in evolution to meet novel translational demands

    Avihu H Yona et al
    Experimental evolution and systematic sequence analysis of transfer RNA genes reveal that anticodon mutations provide adaptive plasticity to the translation machinery.
    Research Article
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