The phosphate starvation response network in a commensal yeast evolved to expand its downstream targets via changes in the main transcription factor's dependence on its co-activator, potentially altering the physiological response.
Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
The conserved biochemical activity of the duplicate Bab transcription factors were integrated into the regulatory hierarchy of an evolving gene regulatory network by binding site gains in a target gene's cis-regulatory region.
The gene regulatory network controlling directed cell migration in a sea urchin is strikingly similar to a sub-circuit for eye development in Drosophila, suggesting that ancient systems-level controls may be adapted for diverse functions in different animals.
Cell cycle network evolution in a fungal ancestor was punctuated by the arrival of a viral DNA-binding protein that was permanently incorporated into the regulatory network controlling cell cycle entry.
New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.