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    1. Evolutionary Biology

    Evolutionary adaptation to juvenile malnutrition impacts adult metabolism and impairs adult fitness in Drosophila

    Berra Erkosar, Cindy Dupuis ... Tadeusz J Kawecki
    Juvenile and adult metabolism are constrained from evolving independently from each other even in a species that lacks developmental continuity between juvenile and adult organs.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of haploid and diploid populations reveals common, strong, and variable pleiotropic effects in non-home environments

    Vivian Chen, Milo S Johnson ... Gavin Sherlock
    Pleiotropy of adaptive clones isolated from diverse experimental environment.
    1. Evolutionary Biology

    Evolutionary consequences of nascent multicellular life cycles

    Jennifer T Pentz, Kathryn MacGillivray ... William C Ratcliff
    Clonal development, but not aggregation, promotes the transition of Darwinian individuality from cells to groups, emphasizing the fundamental role of initial multicellular life cycles in the evolution of multicellularity.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K

    Matthew T Parker, Sebastian M Fica ... Gordon G Simpson
    A computational approach examines the roles of splicing factors and their association with evolutionary change in splicing.
    1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Landscape of epithelial–mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks

    Kishore Hari, Varun Ullanat ... Mohit Kumar Jolly
    Investigation of regulatory network topology reveals latent design principles of multistable phenotypic landscape.
    1. Structural Biology and Molecular Biophysics

    Three-dimensional flagella structures from animals’ closest unicellular relatives, the Choanoflagellates

    Justine M Pinskey, Adhya Lagisetty ... Daniela Nicastro
    Cryo-electron microscopy reveals previously undescribed structural features of choanoflagellate flagella and provides new insights into flagellar evolution.
    1. Cell Biology
    2. Developmental Biology

    Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling

    Woong Y Hwang, Valentyna Kostiuk ... Mustafa K Khokha
    β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.
    1. Physics of Living Systems

    Self-organized canals enable long-range directed material transport in bacterial communities

    Ye Li, Shiqi Liu ... Yilin Wu
    Mechanochemical coupling between interfacial force and biosurfactant kinetics can coordinate large-scale material transport in primitive life forms, suggesting a new principle to engineer self-organized microbial communities.
    1. Evolutionary Biology

    Novel multicellular prokaryote discovered next to an underground stream

    Kouhei Mizuno, Mais Maree ... Kazuya Morikawa
    A new bacterium isolated from an underground stream shows a novel multicellularity by self-organizing its filamentous cells like a liquid crystal and accommodating daughter cells in a sequential manner, which would be a new extant model of prokaryotic multicellularity.